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KMID : 1234420100380010064
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Korean Journal of Microbiololgy and Biotechnology
2010 Volume.38 No. 1 p.64 ~ p.69
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Translation Inhibition Activity and Antifungal Activity of Korean Propolis
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Goh Ah-Ra
Choi Kap-Seong
Choi Sang-Ki
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Abstract
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It has been known that propolis possesses anti-infective, anti-inflammatory, and anti-oxidative properties. Although antifungal activity of Propolis has already been demonstrated, very few studies has been conducted for action mechanism and its spectrum on fungi. We found that ethanol extract of propolis (EEP) inhibited in vitro translation. Since we also observed the growth inhibition of pathogenic fungi and anti-oxidative properties preliminarily, we try to see where those properties come from. Therefore we extracted the EEP further with chloroform, ethyl acetate and butanol. When their fractions were examined for the growth inhibition of Candida albicans, Saccharomyces cerevisiae, Candida glabrata, Candida lusitaniae, Cryptococcos neoformans, chloroform fraction exhibited the highest anti-fungal as well as anti-oxidative properties. Similarly the chloroform fraction showed highest translation-inhibiting activities among the various Propolis fractions. These data indicate that those properties might come from similar compounds.
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KEYWORD
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Propolis, antifungal, antioxidative, translation
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